Proteomics Hot Takes with Sheri Wilcox, Andreas Huhmer, and Parag Mallick

On the latest episode of the Translating Proteomics podcast, Nautilus VP of Scientific Engagement and proteomics industry expert Sheri Wilcox joins hosts Parag Mallick and Andreas Huhmer for a thought-provoking discussion of their “proteomics hot takes.”

Each “hot take” is a provocative opinion on a topic in proteomics. Specifically, they cover:

• Insufficient biological validation is one of the biggest problems in proteomics
• Antibody validation remains a distributed, inconsistent, lab-by-lab responsibility, and this model for validation may not be sustainable going forward.
• AI cell models are overhyped

Check out the episode for deep explorations of each of these hot takes and their potential remedies.

After listening, be sure to let us know whether you agree, disagree, or have your own hot take to share!

Find this episode on Apple Podcasts, Spotify, YouTube, or wherever else you get your podcasts.

Chapters

00:00 – Intro

01:26 – Sheri Wilcox’s hot take – Insufficient biological validation is one of the biggest problems in proteomics

15:31 – Andreas Huhmer’s hot take – Current means of antibody validation may not be sustainable going forward

33:00 – Parag Mallick’s hot take – AI cell models are overhyped

47:18 – Outro

Resources

• Antibodypedia – Resource containing information about publically available research antibodies
• The Human Protein Atlas – Resource cataloguing
• Enhanced validation of antibodies for research applications – Paper from The International Working Group on Antibody Validation (IWGAV) covering 5 proposed pillars for antibody validation
• Gene Expression Omnibus (GEO) – Functional genomics repository where researchers routinely deposit RNA-seq data
• MIAME and MINSEQE guidelines – Guidelines for minimum information that should be included when reported microarray and sequencing data
• AI and Statistics in Proteomics and Systems Biology – Interview with Professor Olga Vitek Ph.D.