Reimagining Proteomics

Nautilus Biotechnology seeks to revolutionize biomedical research by delivering a single-molecule proteomics platform for analyzing and quantifying the human proteome. We were founded on the belief that incremental improvements to existing technologies will not suffice; that a bold scientific leap is required to radically reinvent proteomics.

Our first-generation platform is designed to deliver superior sensitivity more quickly, more completely, and less expensively than is currently possible. By democratizing proteomics, Nautilus seeks to enable a dramatic acceleration of basic science research, significantly improve the speed and success rate of therapeutic development, and contribute to advancements in personalized and predictive medicine.

The Need for a Radical Breakthrough in Proteomics

Drug Discovery

Therapeutic Development

Approximately 95% of FDA-approved drug targets are proteins. Despite a nearly three-fold increase in global R&D spend since 2002, the number of new drugs approved each year has not increased proportionally.

A dramatic increase in sensitivity could enable researchers to observe and better understand proteins that are effectively the “dark matter” of today’s drug development efforts. Doing so could lead to more efficient, cost-effective, and efficacious pharma R&D programs.


Despite the many hundreds of thousands of biomarker research studies estimated to have been published, there are only approximately 100 unique pharmacogenomic biomarkers with FDA approval for use with therapies today.

A breakthrough increase in throughput could enable researchers to more deeply measure large cohorts, thereby powering studies at the scale required to quickly and cost-effectively discover new diagnostics.

Diagnostics blood
Basic Research beaker

Basic Science Research

The inability to easily and reliably quantify the proteins that drive every aspect of human physiology has been a significant impediment to a greater understanding of cellular and organismic biology.

A democratization of proteomics could make it possible for the entire scientific community to undertake a wider range of high-value scientific inquiries, thereby accelerating research.

What is Proteomics?

Proteomics is the large-scale study of the proteome: the tens of thousands of proteins expressed within a cell, tissue, or organism. The proteome is highly varied and dynamically changing across every cell in the human body every moment of every day. Understanding proteins and how they are controlled is critical because they are the functional drivers of every aspect of human physiology, from how we develop in the womb to how susceptible we are to disease.

Nautilus seeks to revolutionize proteomics, transform the way drugs are developed, and significantly improve the way human health is managed.