Reveal hidden biology

More comprehensive views of the proteome in every experiment

Voyager Platform - Nautilus instrument
Meet the VoyagerTM Platform

Accurate single-molecule quantification of proteins and proteoforms

The Nautilus Voyager Platform uses Iterative Mapping to transform proteomics. It is designed for broad proteome coverage with exceptional detail and to deliver reproducible, easy-to-interpret digital counts that support the rapid generation of deep biological insights.

Discover How Iterative Mapping Works

Drive breakthroughs across biology

USE CASES

Explore uncharted biology

Drug development

Iterative Mapping is designed to accurately and reproducibly reveal the proteins and proteoforms that drive disease potentially uncovering promising drug targets and enhancing the efficiency of drug development.

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Biomarker discovery

Iterative Mapping is designed to give researchers the ability to track how proteins and proteoforms change over the course of any disease and identify proteomic signatures of disease progression as well as treatment efficacy.

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Exploratory research

Proteins drive biology, yet countless studies have shown that protein levels cannot be predicted from the genome or transcriptome alone. Iterative Mapping is designed to enable researchers in any lab to potentially obtain the comprehensive views of the proteome required to understand biological function.

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  • Drug development

  • Biomarker discovery

  • Exploratory research

Comprehensive proteome coverage with exceptional detail

RESOURCES

Dive deeper into the science behind Iterative Mapping

January 28, 2026 Press Release

Nautilus Biotechnology and Weill Cornell Medicine-Qatar Collaborate with The Michael J. Fox Foundation to Advance Single-Molecule Proteomics Research in Parkinson’s Disease

Nautilus Biotechnology; Weill Cornell Medicine-Qatar (WCM-Q); and The Michael J. Fox Foundation for Parkinson’s Research (MJFF) today announced a research collaboration to study the connection between the alpha-synuclein (aSyn) protein and Parkinson’s disease (PD). Click here to read the press release.
Early Access Program

Nautilus Iterative Mapping Early Access Program

Join the Iterative Mapping Early Access Program and be one of the first to achieve single-molecule proteomic insights.

Large-scale single-molecule analysis of tau proteoforms

Learn how Iterative Mapping enables quantitative, sensitive, and reproducible analysis of high- and low-abundance tau proteoforms on the Nautilus Proteome Analysis Platform.
January 14, 2026

Advancing next-generation proteomics with single-molecule Iterative Mapping

In this webinar, Dr. Birgit Schilling, Professor and Director of the Mass Spectrometry Core at the Buck Institute for Research on Aging, shares how her laboratory is applying Iterative Mapping to investigate tau proteoforms and their role in aging and age-associated neurodegenerative disease. She discusses how molecule-level protein analysis is enabling new insights into proteoform heterogeneity and biological function that are difficult to achieve using conventional proteomic approaches.
Animation
Protein attached to a nanoparticle on a massive protein array. The protein is bound by a probe that provides information about its identity.

Quantifying proteins and proteoforms with Iterative Mapping on the Nautilus Platform

Discover how we use Iterative Mapping to quantify proteins and proteoforms on the Nautilus Platform
White paper

Proteomics at scale: Current approaches and emerging technologies

We outline the primary advantages and challenges of current proteomics technologies and discuss measures needed to enable quantification of the proteome at depths substantially greater than the 8-30% of the proteome that is readily accessible today.
Tech Note
Tech Note front page

Iterative Mapping of proteoforms

Explore the quantitative benefits of Iterative Mapping of proteoforms including its accuracy, sensitivity, dynamic range, and reproducibility.
Animation
Diagram of the brain overlaid on proteins arrayed on the Nautilus Proteome Analysis Platform

Unlocking the potential of proteomics to fuel neuroscience research

Watch this animation to learn how next-generation proteomics technologies can fuel neuroscience research and enable biomarker and drug development.

Revolutionize proteomics and be one of the first to apply Iterative Mapping in your research

Join our Early Access Program