Reimagining Proteomics

Nautilus Biotechnology will ignite a transformation in biomedical research by delivering a high-throughput, low-cost platform for analyzing and quantifying the human proteome.

Our first-generation platform will deliver superior sensitivity far more quickly, more completely, and less expensively than is currently possible. By breaking through the limitations of existing technologies, and effectively democratizing proteomics, Nautilus will enable a dramatic acceleration of basic science research, significantly improve the speed and success rate of therapeutic development, and usher in a new era of personalized and predictive medicine.

The Need for a Radical Breakthrough in Proteomics

Drug Discovery

Therapeutic Development

90% of FDA-approved drugs target a protein. Despite a nearly four-fold increase in global R&D spend from 2000-2020, the number of new drugs approved each year has not increased appreciably. In addition, after 10-15 years in development, only 2 of 10 marketed drugs return revenues that match or exceed their R&D costs.

A dramatic increase in sensitivity will enable researchers to observe and better understand proteins that are effectively the “dark matter” of today’s drug development efforts. Doing so will lead to more efficient, cost-effective, and efficacious pharma R&D programs.


Despite an estimated 150,000 papers documenting thousands of claimed biomarkers, there are only approximately 100 blood-based biomarkers in routine clinical use today.

A breakthrough increase in throughput will enable researchers to more deeply measure large cohorts, thereby powering studies at the scale required to quickly and cost-effectively discover new diagnostics.

Diagnostics blood
Basic Research beaker

Basic Science Research

The inability to easily and reliably quantify the proteins that drive every aspect of human physiology has been a massive impediment to a greater understanding of cellular and organismic biology.

A democratization of proteomics will make it possible for the entire scientific community to undertake a wider range of high-value scientific inquiries, thereby accelerating research.

What is Proteomics?

Proteomics is the large-scale study of the proteome: the tens of thousands of proteins expressed within a cell, tissue, or organism. The proteome is highly varied and dynamically changing across every cell in the human body every moment of every day. Understanding proteins and how they are controlled is critical because they are the functional drivers of every aspect of human physiology, from how we develop in the womb to how susceptible we are to disease.

Nautilus is positioned to revolutionize proteomics, transform the way drugs are developed, and significantly improve the way human health is managed.