Tau proteoform analysis – Key takeaways from our recent Nature Methods publication
Nautilus Biotechnology
September 17, 2026
Translating Proteomics hosts Parag Mallick and Andreas Huhmer discuss our new Nature Methods paper, “Large-scale single-molecule analysis of tau proteoforms.” This publication describes how the Nautilus Voyager™ Platform can be used to quantify proteoforms derived from the neurodegeneration-associated tau protein. These proteoforms are defined by their unique combinations of post-translational modifications and isoform specific sequences. They may make powerful next-generation biomarkers or drug targets, but few technologies can measure them today.
In the episode, Parag and Andreas discuss:
What proteoforms are and why it’s critical to study them to understand biology.
How the Nautilus Voyager™ Platform quantifies proteoforms.
The key findings from the tau proteoform analyses in the paper.
Potential applications of these findings.
The Nautilus Voyager™ Platform as a powerful foundational technology.
