Generating a mechanistic understanding of cancer through proteomics
Genomics research has helped cement cancer’s roots as a genetic disease, enabled researchers to discover many cancer-driving mutations, and driven inspiring successes in the field of precision medicine
Nonetheless, many cancer patients still don’t have effective precision medicines or do not achieve durable responses (see Rodriguez et al. for an overview of successes and gaps in precision medicines for cancer). Given that proteins are the molecular machines that control most biological functions, and most drugs target proteins, it makes intuitive sense to look to the proteome to better understand the biology of cancer and find the appropriate pathways to drug in individual patients.
In this eBook, we distill results from a variety of recent proteomic investigations of cancer. These studies are often conducted through the Clinical Proteomic Tumor Analysis Consortium and are monumental efforts involving many skilled researchers. Their findings make it clear that proteomics is well-positioned to identify vulnerabilities in cancer and direct the development of novel therapeutics and diagnostics.
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