Knowledge Center

Find content exploring the innovations underlying our novel technology

Manuscripts

A theoretical framework for proteome-scale single-molecule protein identification using multi-affinity protein binding reagents

Demonstrates the potential of our technology to efficiently decode greater than 95% of the proteome.

Highly dense and scalable protein arrays for single-molecule studies

Outlines the critical process of depositing single protein molecules uniformly and completely across the 10 billion ‘landing pads’ on our platform’s high quality, hyper-dense, single-molecule protein arrays.

Modular fluorescent nanoparticle DNA probes for detection of peptides and proteins

This work introduces a straightforward approach for preparation of fluorescent nanoparticle probes using commercially available reagents and common laboratory equipment.
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Tech notes

Hyper-dense single-molecule protein arrays for proteomics at scale

Learn how we create arrays with billions of landing pads that isolate single protein molecules.

PrISM – A novel method for single-molecule protein identification and quantification at scale

Here we describe a method to measure substantively all of the proteome using a technique called Protein Identification by Short Epitope Mapping (PrISM).
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White papers and eBooks

WHITE PAPER

Proteomics at scale: Current approaches and emerging technologies

We outline the primary advantages and challenges of current proteomics technologies and discuss measures needed to enable quantification of the proteome at depths substantially greater than the 8-30% of the proteome that is readily accessible today.
Ebook

Proteomics and cancer

Learn how proteomics is advancing cancer research and may usher in the creation of new cancer diagnostics and treatments.
Ebook

Proteomics and neuroscience

Learn how proteomics is advancing the study of the brain and broader nervous system and how next-generation proteomics can accelerate basic and applied neuroscience.
WHITE PAPER

Proteomics and the development of precision medicines against cancer

Learn how proteomics can drive the creation of precision medicines that more rapidly identify and treat the molecular causes of cancer.
WHITE PAPER

Accelerating basic research with proteomics

Learn how proteomics makes it possible for scientists to better understand the complexities of biology and create new therapeutics, biotechnologies, and metrics of human health.
WHITE PAPER

Unlocking the complexity of proteins to fuel precision medicine

Discover how unlocking the complexity of proteins can radically improve how we identify targets for drug development.
WHITE PAPER

Using proteomics to personalize medicine across the continuum of care

Find out why proteins – the drivers of our health – are key to unlocking a new era of effective diagnostics and care.
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Videos

Nautilus platform animation

Get a broad overview of the technology underlying the Nautilus Proteome Analysis Platform.
Precision medicine animation still

Unlocking the complexity of proteomics to fuel precision medicine

Learn how next-generation proteomics can spur a revolution in precision medicine.
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Webinars

Single-Molecule Proteomics using Protein Identification by Short-epitope Mapping

The field of proteomics is poised for a single-molecule revolution – enabling more comprehensive analysis of the proteins in a sample with increased sensitivity, reproducibility, and accessibility.

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