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Reflections on Proteomics – 2025 Year-End Wrap-Up

Nautilus Biotechnology

Nautilus Biotechnology

December 23, 2025


On this episode of Translating Proteomics, Parag and Andreas share their reflections on proteomics developments in 2025 largely inspired by their observations at the World HUPO 2025 conference in Toronto. Whether you agree, disagree, or simply want to share some of your own observations on proteomics, please post your thoughts in the comments on YouTube. We look forward to even more exciting developments in 2026!

Subscribe to Translating Proteomics on YouTube, Apple Podcasts, Spotify.

Chapters

00:00 – 00:35 – Intro

00:36 – 07:00 – Increased focus on applications of proteomics and less on method development
Learn more about One Health from our conversation with Professor Jennifer Geddes-McAlister:
https://youtu.be/JFwvTdkb5bw

07:01 – 12:47 – Increase in people talking about the importance of proteoforms
Learn more about proteoforms in our episode featuring proteoform pioneer Professor Neil Kelleher:
https://youtu.be/3pPuxVrMxpw

12:47 – 17:26 – An increase in multiomics studies

17:27 – 20:03 – A shift to larger scale proteomics studies
For a great example of a multi-platform comparison study, check out Kirsher et al., 2025:
https://www.nature.com/articles/s42004-025-01665-1

20:03 – 25:07 – Increased integration of AI into proteomics workflows
For an example of how proteomics workflows can be modified with multiomic data, check out Suhre et al., 2025:
https://www.nature.com/articles/s41588-025-02413-w

25:08 – 30:05 – Recognition of the need to assess quality across proteomics workflows

30:06 – 32:19 – Less of a focus on spatial proteomics this year than in past years

32:20 – 35: 13 – Parag and Andreas share their predictions for 2026

35:14 – End – Outro

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