Single Molecule Biophysicist

San Carlos, CA

This is an opportunity to play a significant role in helping Nautilus Biotechnology develop our single molecule fluorescent based technology. The core responsibilities for the successful candidate will be to work with the Assay team to improve our reagent formulations to increase the sensitivity of our platform. The scope of the work will also include collaborating with the Engineering team to improve the optical properties of the materials used in the platform. The nature of this position will be highly dynamic, providing the successful candidate an opportunity to push the technology forward while immersing themselves in these teams.

Job Description

Role and Responsibilities:
  • Be our internal expert on measuring single molecules using a fluorescence-based detection system
  • Responsible for determining the optimal measurement conditions for our protein targets
  • Work collaboratively with the Assay and Engineering teams to improve our limits of detection
Qualifications and Education Requirements:

The successful candidate should hold a PhD degree in Biophysics, Biochemistry, Physics or other related discipline. Candidates holding MS or BS degrees in relevant disciplines with 7+ years of single molecule fluorescence detection experience are also encouraged to apply.

Significant hands on experience using single molecule fluorescence-based systems

A deep understanding of protein-protein interactions, thermodynamics and kinetics

Preferred Skills:
  • Single molecule detection experience
  • Strong troubleshooting and critical thinking skills
  • Ability to work effectively and collaboratively with colleagues from many disciplines
  • Previous experience in a systems integration role is a big plus

Does this sound like you?

Apply Now

Organizational Values

At Nautilus, our core values are pretty simple...

  • Be kind. No a**holes!
  • Tackle the big, hard thing
  • Invest in exceptional people
  • Assume and radiate good intent
  • EVERY voice matters
  • Take care of yourself
  • Have fun, make a difference, be happy!


  • 401(k)
  • New Parent Leave
  • Commuter Benefits
  • 100% premiums covered for medical, dental and vision
  • Responsible PTO
  • 10 paid holidays per year
  • Team Events

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