Protein Biophysics Scientist

San Carlos, CA

Nautilus is studying a large number of antibodies and related molecules for use in our proteomics platform. We are looking for a scientist to perform and manage the analysis and characterization of these antibodies. Antibody analysis will include a variety of techniques including ELISA assays, kinetic binding constant determination (SPRi, Biacore, ITC etc), and profiling to define binding antigens and non-binding antigens in high or moderate-throughput format. There are also projects involving antibody engineering and chemical modification. The candidate will work with that team to optimize engineering goals, methods (phage display, rational design, computational design), screening workflows, and characterization of antibody variants.

Job Description

Role and Responsibilities:
  • Develop and execute antibody analysis (workflows, multiparameter analysis) for a number of antibodies and related molecules
  • Characterize binding and non-binding interaction affinities under a range of conditions relevant for our proteomics assay
  • Characterize the thermodynamic and kinetic constants of antigen/antibody interactions (SPR, ITC, BLI, MST)
  • Be an integral member of an antibody engineering team focused on developing antibodies to meet specific requirements for our proteomics assay
  • Work cross-functionally with other research teams to align antibody performance with proteomics assay needs
Qualifications and Education Requirements:
  • A minimum of 3 years of experience characterizing, engineering, or studying multiple antibodies
  • Ability to manage, prioritize and analyze complex workflows for large numbers of molecules
  • Expertise in antibody/antigen binding analysis and characterization using one or more standard instrumental methods
  • Experience working in a dynamic research environment with rapidly evolving needs and specifications
  • Ability to build workflows for others to execute
  • Effectively present and report your findings internally and at scientific meetings


Preferred Skills:
  • Experience engineering antibodies is a plus

Does this sound like you?

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Organizational Values

At Nautilus, our core values are pretty simple...

  • Be Nice. No a**holes!
  • Tackle the big, hard thing
  • EVERY voice matters
  • There are no passengers
  • Don’t put off till tomorrow what you can do today
  • Assume and radiate good intent
  • Take care of yourself and your teammates
  • Have fun, enjoy the voyage, make a difference, be happy!
  • Science/engineering is a team sport
  • All hands on deck!


  • 401(k)
  • New Parent Leave
  • Commuter Benefits
  • 100% premiums covered for medical, dental and vision
  • Responsible PTO
  • 10 paid holidays per year
  • Team Events

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