Principal Mechanical Engineer

San Carlos, CA

This is an opportunity to play a significant role in helping Nautilus Biotechnology develop our single molecule fluorescent based proteomics technology. The role is that of a player coach. The ideal candidate will be able to successfully balance both contributing as an engineer along with helping to manage the day-to-day activities of the Engineering team. Strong technical skills in the areas of mechanical and optical engineering along with microfluidics will be needed to help set team member’s priorities and provide advice on solving complicated problems. The successful candidate will work collaboratively across functional areas with additional team members and managers to facilitate communication of technical progress, project timelines and any mitigation plans that may be required.

Job Description

Role and Responsibilities:
  • Using systems level thinking, anticipate future system requirements and needs and create interdisciplinary project plans to meet these long term needs
  • Be our internal subject matter expert on mechanical, optical and microfluidic design
  • Refine systems requirement documentation as new requirements are discovered
  • Help manage day-to-day activities of team members to achieve team objectives
Qualifications and Education Requirements:
  • The successful candidate should hold a degree in Engineering, Physics, or other related discipline with 10 or more years
  • Strong communication and critical thinking skills
  • Expertise in optics, fluidics and mechanical engineering


Preferred Skills:
  • Worked as a project lead, provided mentoring to less experienced engineers
  • Experience developing an interdisciplinary diagnostic platform is highly preferred
  • Previous project planning experience is a plus

Does this sound like you?

Apply Now

Organizational Values

At Nautilus, our core values are pretty simple...

  • Be Nice. No a**holes!​
  • EVERY voice matters​
  • Tackle the big, hard thing​
  • Do the right thing – act with integrity​
  • Be kind – take care of yourself and your teammates​
  • Approach every day with grit and urgency​
  • Have fun, enjoy the voyage, make a difference, be happy!


  • 401(k)
  • New Parent Leave
  • Commuter Benefits
  • 100% premiums covered for medical, dental and vision
  • Responsible PTO
  • 10 paid holidays per year
  • Team Events

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